Ethanol → HCID 178457393, compound

HRID 868579Notes

Reaction equation

[CH:1]([N:4]([CH:18]([CH3:20])[CH3:19])[CH2:5][CH2:6][N:7]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:10](=O)[C:8]1=[O:9])([CH3:3])[CH3:2].[C:21]1([NH:27][C:28](=[O:31])[NH:29][NH2:30])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.C(O)C>C(O)(=O)C.O>[C:21]1([NH:27][C:28](=[O:31])[NH:29]/[N:30]=[C:10]2/[C:8](=[O:9])[N:7]([CH2:6][CH2:5][N:4]([CH:18]([CH3:20])[CH3:19])[CH:1]([CH3:3])[CH3:2])[C:17]3[C:12]/2=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

Participants

Conditions

Temperature: 70 °C

Procedure

To a solution of 1.37 g of 1-(2-diisopropylaminoethyl)isatin and 0.86 g of 4-phenylsemicarbazide in ml of a mixture of ethanol and water (2:1) was added 3 drops of acetic acid, and the mixture was stirred for 3 hours at 70° C. The yellow precipitates were collected by filtration, and recrystallized from ethanol to obtain 1.24 g of (E)-1-(2-diisopropylaminoethyl)isatin 3-(4-phenylsemicarbazone) having a melting point of 157°-159° C.

Workup

customThe yellow precipitates
filtrationwere collected by filtration
customrecrystallized from ethanol

Sources & evidence

ORD record: ord-055cec70f49441c5a06472344904869f
Source dataset: uspto-grants-1988_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04780477

Reaction notes

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