反应详情

A suspension of 10.00 g of 1-(2-diisopropylaminoethyl)isatin and 4.88 g of semicarbazide hydrochloride in 350 ml of a mixture of ethanol and water (2.5:1) was stirred for 2 hours at room temperature. The suspension was warmed to make a solution, and then 44.0 ml of a 1N-aqueous sodium hydroxide solution was added dropwise to the solution. The precipitates were collected by filtration and washed with water to obtain 10.56 g of (E)-1-(2-diisopropylaminoethyl)isatin 3-semicarbazone. The chemical properties of this product were identical with those of the product obtained by Examle 1.

1. temperatureThe suspension was warmed
2. filtrationThe precipitates were collected by filtration
3. washwashed with water