Ethanol → HCID 178457379, compound

HRID 868586Notes

Reaction equation

HRID 868586 reaction equation
[CH:1]([N:4]([CH:18]([CH3:20])[CH3:19])[CH2:5][CH2:6][N:7]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:10](=O)[C:8]1=[O:9])([CH3:3])[CH3:2].Cl.[NH2:22][NH:23][C:24]([NH2:26])=[O:25].C(O)C.[OH-].[Na+]>O>[CH:1]([N:4]([CH:18]([CH3:20])[CH3:19])[CH2:5][CH2:6][N:7]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)/[C:10](=[N:22]\[NH:23][C:24]([NH2:26])=[O:25])/[C:8]1=[O:9])([CH3:3])[CH3:2]

Participants

6

Reactant 4

HCID 702EthanolHCID 11236Semicarbazide hydrochlorideHCID 14798Sodium HydroxideHCID 139344081-(2-Diisopropylaminoethyl)isatin

Product 1

HCID 178457379HCID 178457379, compoundYield 87.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A suspension of 10.00 g of 1-(2-diisopropylaminoethyl)isatin and 4.88 g of semicarbazide hydrochloride in 350 ml of a mixture of ethanol and water (2.5:1) was stirred for 2 hours at room temperature. The suspension was warmed to make a solution, and then 44.0 ml of a 1N-aqueous sodium hydroxide solution was added dropwise to the solution. The precipitates were collected by filtration and washed with water to obtain 10.56 g of (E)-1-(2-diisopropylaminoethyl)isatin 3-semicarbazone. The chemical properties of this product were identical with those of the product obtained by Examle 1.

Workup

  1. temperatureThe suspension was warmed
  2. filtrationThe precipitates were collected by filtration
  3. washwashed with water

Sources & evidence

ORD record
ord-7298f8709a9940369b8d2db3c18d8c57
Source dataset
uspto-grants-1988_10
Patent number
US04780477

Reaction notes

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