Semicarbazide hydrochloride → HCID 178457383, compound

HRID 868596Notes

Reaction equation

[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](=O)[C:7](=[O:20])[N:8]2[CH2:11][CH2:12][N:13]([CH:17]([CH3:19])[CH3:18])[CH:14]([CH3:16])[CH3:15])=[CH:4][CH:3]=1.Cl.[NH2:23][NH:24][C:25]([NH2:27])=[O:26]>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5](/[C:6](=[N:23]\[NH:24][C:25]([NH2:27])=[O:26])/[C:7](=[O:20])[N:8]2[CH2:11][CH2:12][N:13]([CH:17]([CH3:19])[CH3:18])[CH:14]([CH3:16])[CH3:15])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 11236Semicarbazide hydrochloride

HCID 13934413HCID 13934413, compound

Product 1

HCID 178457383HCID 178457383, compoundYield 69.4%

Procedure

By using 6-chloro-1-(2-diisopropylaminoethyl)isatin and semicarbazide hydrochloride, a method analogous to that described in Example 4 was carried out to obtain (E)-6-chloro-1-(2-diisopropylaminoethyl)isatin 3-semicarbazone having a melting point of 205°-208° C. (yield: 69.4%, recrystallizing solvent: aqueous methanol).

Sources & evidence

ORD record: ord-77d575b011d54cbfb342e0df824cf1d1
Source dataset: uspto-grants-1988_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04780477

Reaction notes

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