Semicarbazide hydrochloride → HCID 178457373, compound

HRID 868597Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][CH2:12][N:13]([CH:17]([CH3:19])[CH3:18])[CH:14]([CH3:16])[CH3:15])[C:6](=[O:20])[C:5]2=O.Cl.[NH2:23][NH:24][C:25]([NH2:27])=[O:26]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][CH2:12][N:13]([CH:17]([CH3:19])[CH3:18])[CH:14]([CH3:16])[CH3:15])[C:6](=[O:20])/[C:5]/2=[N:23]/[NH:24][C:25]([NH2:27])=[O:26]

Participants

Reactant 2

HCID 11236Semicarbazide hydrochloride

HCID 139344155-Bromo-1-(2-diisopropylaminoethyl)isatin

Product 1

HCID 178457373HCID 178457373, compoundYield 72.6%

Procedure

By using 5-bromo-1-(2-diisopropylaminoethyl)isatin and semicarbazide hydrochloride, a method analogous to that described in Example 4 was carried out to obtain (E)-5-bromo-1-(2-diisopropylaminoethyl)isatin 3-semicarbazone having a melting point of 149°-153° C. (yield: 72.6%, recrystallizing solvent: chloroform-hexane).

Sources & evidence

ORD record: ord-128474ca64da414d83138e367f3c306b
Source dataset: uspto-grants-1988_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04780477

Reaction notes

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