3-Amino-1-cyclohexylurea → HCID 178457391, compound

HRID 868598Notes

Reaction equation

HRID 868598 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][CH2:12][N:13]([CH:17]([CH3:19])[CH3:18])[CH:14]([CH3:16])[CH3:15])[C:6](=[O:20])[C:5]2=O.[CH:22]1([NH:28][C:29](=[O:32])[NH:30][NH2:31])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>>[CH:22]1([NH:28][C:29](=[O:32])[NH:30]/[N:31]=[C:5]2/[C:6](=[O:20])[N:7]([CH2:11][CH2:12][N:13]([CH:17]([CH3:19])[CH3:18])[CH:14]([CH3:16])[CH3:15])[C:8]3[C:4]/2=[CH:3][C:2]([Br:1])=[CH:10][CH:9]=3)[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]1

Participants

3

Reactant 2

HCID 2618793-Amino-1-cyclohexylureaHCID 139344155-Bromo-1-(2-diisopropylaminoethyl)isatin

Product 1

HCID 178457391HCID 178457391, compoundYield 89.9%

Procedure

By using 5-bromo-1-(2-diisopropylaminoethyl)isatin and 4-cyclohexylsemicarbazide, a method analogous to that described in Example 16 was carried out to obtain (E)-5-bromo-1-(2-diisopropylaminoethyl)isatin 3-(4-cyclohexylsemicarbazone) having a melting point of 155°-156° C. (yield: 89.9%, recrystallizing solvent: chloroform-hexane).

Sources & evidence

ORD record
ord-a51baaacf38343099bc5433bdc59b105
Source dataset
uspto-grants-1988_10
Patent number
US04780477

Reaction notes

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