Semicarbazide hydrochloride → HCID 178422414, compound

HRID 868603Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([CH3:22])[CH:5]=[C:6]2[C:10]=1[N:9]([CH2:11][CH2:12][N:13]([CH:17]([CH3:19])[CH3:18])[CH:14]([CH3:16])[CH3:15])[C:8](=[O:20])[C:7]2=O.Cl.[NH2:24][NH:25][C:26]([NH2:28])=[O:27]>>[Br:1][C:2]1[CH:3]=[C:4]([CH3:22])[CH:5]=[C:6]2[C:10]=1[N:9]([CH2:11][CH2:12][N:13]([CH:17]([CH3:19])[CH3:18])[CH:14]([CH3:16])[CH3:15])[C:8](=[O:20])/[C:7]/2=[N:24]/[NH:25][C:26]([NH2:28])=[O:27]

Participants

Reactant 2

HCID 11236Semicarbazide hydrochloride

HCID 13934419HCID 13934419, compound

Product 1

HCID 178422414HCID 178422414, compoundYield 87.9%

Procedure

By using 7-bromo-1-(2-diisopropylaminoethyl)-5-methylisatin and semicarbazide hydrochloride, a method analogous to that described in Example 4 was carried out to obtain (E)-7-bromo-1-(2-diisopropylaminoethyl)-5-methylisatin 3-semicarbazone having a melting point of 189°-192° C. (yield: 87.9%, recrystallizing solvent: chloroform-hexane)

Sources & evidence

ORD record: ord-7fa56d7f977b4dfa9596d1a74cec2539
Source dataset: uspto-grants-1988_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04780477

Reaction notes

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