Aspartame → HCID 68116332, compound

HRID 868643Notes

Reaction equation

HRID 868643 reaction equation
[ClH:1].COC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](C)N.[CH3:28][O:29][C:30](=[O:54])[C@H:31]([CH2:47][C:48]1[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=1)[NH:32][C:33](=[O:46])[C@H:34]([CH2:42][C:43](=[O:45])[OH:44])[NH:35][C:36](=[O:41])[C@@H:37]([CH2:39][OH:40])[NH2:38].COC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CC(=O)O)N>>[ClH:1].[CH3:28][O:29][C:30](=[O:54])[C@H:31]([CH2:47][C:48]1[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=1)[NH:32][C:33](=[O:46])[C@H:34]([CH2:42][C:43](=[O:44])[OH:45])[NH:35][C:36](=[O:41])[C@@H:37]([CH2:39][OH:40])[NH2:38]

Participants

4

Reactant 3

HCID 134601AspartameHCID 14151456HCID 14151456, compoundHCID 68116305HCID 68116305, compound

Product 1

HCID 68116332HCID 68116332, compound

Procedure

In a manner similar to Example 2 (B) and (C), 2.3 g of D-seryl-α-L-aspartyl-L-phenylalanine methyl ester was obtained from 2.4 g of N-t-butoxycarbonyl-D-serine N-hydroxy succinimide ester prepared in a manner similar to Example 2 (A) and 3.0 g of α-L-aspartyl-L-phenylalanine methyl ester.

Sources & evidence

ORD record
ord-50de5a2f2cd04e21815b5dd503e0d259
Source dataset
uspto-grants-1988_10
Patent number
US04780528

Reaction notes

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