N-Benzyloxycarbonyl-D-alanyl-alpha-L-aspartyl-D-alanine isopropyl ester → D-Alanyl-alpha-L-aspartyl-D-alanine isopropyl ester

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Reaction Steps

N-Benzyloxycarbonyl-D-alanyl-α-L-aspartyl-D-alanine isopropyl ester (2.5 g) was dissolved in 100 ml of 80% aqueous acetic acid, and the solution was subjected to catalytic reduction in a hydrogen gas stream at room temperature for four hours using palladium/carbon as catalyst. After filtering off the catalyst, the filtrate was concentrated to dryness under reduced pressure, affording 1.6 g of white powder. M.p.: 219°-221° C.

Provenance & Evidence