D-Alanyl-alpha-L-aspartyl-D-alanine isopropyl ester → D-Alanyl-alpha-L-aspartyl-D-serine isopropyl ester

HRID 868653Notes

Reaction equation

HRID 868653 reaction equation
[CH:1]([O:4][C:5](=[O:18])[C@@H:6]([CH2:16][OH:17])[NH:7][C:8](=[O:15])[C@H:9]([CH2:11][C:12](=[O:14])[OH:13])[NH2:10])([CH3:3])[CH3:2].C([O:22][C:23](=O)[C@@H:24]([CH3:39])[NH:25]C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](C)N)(C)C>>[CH:1]([O:4][C:5](=[O:18])[C@@H:6]([CH2:16][OH:17])[NH:7][C:8](=[O:15])[C@H:9]([CH2:11][C:12](=[O:13])[OH:14])[NH:10][C:23](=[O:22])[C@@H:24]([CH3:39])[NH2:25])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 14151478D-Alanyl-alpha-L-aspartyl-D-alanine isopropyl esterHCID 22840263alpha-L-aspartyl-D-serine isopropyl ester

Product 1

HCID 14151482D-Alanyl-alpha-L-aspartyl-D-serine isopropyl ester

Procedure

This compound was prepared from 1.9 g α-L-aspartyl-D-serine isopropyl ester and 2.2 g N-benzyloxycarbonyl-D-alanine N-hydroxysuccinimide ester in a manner similar to Example 16 (C) and (D). Yield: 1.8 g, m.p.: 222.5°-234° C.

Sources & evidence

ORD record
ord-70b89acd0aa44a51a7176d2279d8acfb
Source dataset
uspto-grants-1988_10
Patent number
US04780528

Reaction notes

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