Diethyl Ether → alpha-Aminoisobutyryl-alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride

HRID 868654Notes

Reaction equation

HRID 868654 reaction equation
[CH3:1][O:2][C:3](=[O:34])[C@H:4]([CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[NH:5][C:6](=[O:26])[C@:7]([NH2:25])([CH2:21][C:22](=[O:24])[OH:23])[N:8]([C:16](=[O:20])[CH:17]([CH3:19])[CH3:18])C(OC(C)(C)C)=O.C(OCC)C.[ClH:40].O1CCOCC1>>[ClH:40].[CH3:1][O:2][C:3](=[O:34])[C@H:4]([CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[NH:5][C:6](=[O:26])[C@:7]([NH2:25])([CH2:21][C:22](=[O:23])[OH:24])[NH:8][C:16](=[O:20])[CH:17]([CH3:19])[CH3:18]

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 204431481,4-Dioxane hydrochlorideHCID 86742498N-t-Butoxycarbonyl-alpha-aminoisobutyryl-alpha-L-aspartyl-L-phenylalanine methyl ester

Product 1

HCID 86742496alpha-Aminoisobutyryl-alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride

Procedure

N-t-Butoxycarbonyl-α-aminoisobutyryl-α-L-aspartyl-L-phenylalanine methyl ester (2.3 g) was dissolved under ice cooling in 4N-HCl/dioxane (20 ml), and the mixture was stirred for one hour. Ethyl ether (150 ml) was added, and the crystals which separated out were collected by filtration. Yield: 1.8 g.

Workup

  1. customthe crystals which separated out
  2. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-9420468f2cc24fab94325a02404cd791
Source dataset
uspto-grants-1988_10
Patent number
US04780528

Reaction notes

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