HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Phenylmethyl) hydrogen N-((phenylmethoxy)carbonyl)-L-aspartate → alpha-Aminoisobutyryl-alpha-L-aspartyl-D-serine ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Phenylmethyl) hydrogen N-((phenylmethoxy)carbonyl)-L-aspartate | HCID 47602 | — |
| Reactant | ethyl (2R)-2-amino-3-hydroxypropanoate hydrochloride | HCID 56965749 | — |
| Reactant | alpha-Aminoisobutyryl-alpha-L-aspartyl-L-phenylalanine methyl ester | HCID 86742497 | — |
| Product | alpha-Aminoisobutyryl-alpha-L-aspartyl-D-serine ethyl ester | HCID 86742500 | — |
Reaction Steps
This compound was prepared from 1.7 g D-serine ethyl ester hydrochloride, 3.6 g Z-Asp(OBzl) and 1.8 g N-t-butoxycarbonyl-α-aminoisobutyric acid N-hydroxysuccinimide ester in a manner similar to Example 20 (A), (C), (D) and (E). Yield: 1.2 g, m.p.: 175°-178° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04780528 |
| Source dataset | uspto-grants-1988_10 |
| ORD ID | ord-a3a4ea3a137c4b05a9877baffb48e94a |
| Source note | uspto-grants-1988_10 |