alpha-L-Aspartyl-D-alanine propyl ester → D-Alanyl-alpha-L-aspartyl-D-alanine n-propyl ester

HRID 868659Notes

Reaction equation

HRID 868659 reaction equation
[CH2:1]([O:4][C:5](=[O:17])[C@@H:6]([CH3:16])[NH:7][C:8](=[O:15])[C@H:9]([CH2:11][C:12](=[O:14])[OH:13])[NH2:10])[CH2:2][CH3:3].Cl.C[O:20][C:21](=O)[C@H:22]([CH2:38]C1C=CC=CC=1)[NH:23]C(=O)[C@](N)(CC(=O)O)NC(=O)C(C)C>>[CH2:1]([O:4][C:5](=[O:17])[C@@H:6]([CH3:16])[NH:7][C:8](=[O:15])[C@H:9]([CH2:11][C:12](=[O:13])[OH:14])[NH:10][C:21](=[O:20])[C@@H:22]([CH3:38])[NH2:23])[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 22840262alpha-L-Aspartyl-D-alanine propyl esterHCID 86742496alpha-Aminoisobutyryl-alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride

Product 1

HCID 14151494D-Alanyl-alpha-L-aspartyl-D-alanine n-propyl ester

Procedure

This compound was prepared from 1.9 g α-L-aspartyl-D-alanine n-propyl ester and 2.2 g N-benzyloxycarbonyl-D-alanine N-hydroxysuccinimide ester in a manner similar to Example 16 (C) and (D). Yield: 1.7 g, m.p.: 223°-225° C.

Sources & evidence

ORD record
ord-811a4df037094d9aa98f6d16fc3620c8
Source dataset
uspto-grants-1988_10
Patent number
US04780528

Reaction notes

Loading…