1,3-Benzodioxole-5-ethanamine → HCID 67938405, compound

HRID 868683Notes

Reaction equation

HRID 868683 reaction equation
[CH2:1]1[O:12][C:11]2[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][NH2:8])=[CH:4][C:3]=2[O:2]1.[C:13]([CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])(=O)[CH2:14][CH3:15]>C(OCC)C>[CH2:1]1[O:12][C:11]2[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][NH:8][C:13]([CH2:14][CH3:15])=[CH:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:4][C:3]=2[O:2]1

Participants

4

Reactant 2

HCID 738741,3-Benzodioxole-5-ethanamineHCID 78656Ethyl 3-oxovalerate

Product 1

HCID 67938405HCID 67938405, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

In a manner similar to that described in Example IV, 5.0 grams (30 millimoles) of 4-(3,4-methylenedioxyphenethylamine is added dropwise with stirring at ambient temperature to 4.5 grams (31 millimoles) of ethyl propionylacetate and the stirring continued for about 12 hours at ambient temperature. Thereafter, the mixture is diluted with 250 milliliters of diethyl ether and the resulting ether solution washed with 50 milliliters of brine and then dried over sodium sulfate. The ether is vaporized off of the dried and filtered solution to obtain ethyl 3-[2-(3,4-methylenedioxyphenyl)ethyl]amino-2-pentenoate.

Workup

  1. additionis added dropwise
  2. washthe resulting ether solution washed with 50 milliliters of brine
  3. dry with materialdried over sodium sulfate
  4. customdried
  5. filtrationfiltered solution

Sources & evidence

ORD record
ord-7dd537a8e749492eaa0b9f920a71cd6e
Source dataset
uspto-grants-1988_10
Patent number
US04780538

Reaction notes

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