O-Toluidine → HCID 67938254, compound

HRID 868684Notes

Reaction equation

[NH2:1][C:2]1[C:3]([CH3:8])=[CH:4][CH:5]=[CH:6][CH:7]=1.[C:9]([O:15][CH3:16])(=[O:14])[CH2:10][C:11]([CH3:13])=O>>[CH3:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH:1]/[C:11](/[CH3:13])=[CH:10]\[C:9]([O:15][CH3:16])=[O:14]

Participants

Reactant 2

HCID 7242O-Toluidine

HCID 7757Methyl acetoacetate

Product 1

HCID 67938254HCID 67938254, compound

Procedure

In a manner similar to that previously described, 96.4 grams (0.9 mole) of o-toluidine is added dropwise to a solution of 116 grams (1 mole) of methyl acetoacetate and the reaction mixture allowed to stand overnight to obtain methyl 3-(2-methylphenyl)aminocrotonate.

Sources & evidence

ORD record: ord-3770560009b24f7daca038e7b976b905
Source dataset: uspto-grants-1988_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04780538

Reaction notes

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