HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Phenylalanine → 3-Carboxymethyl-6-benzyl-2,5-diketopiperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Phenylalanine | HCID 6140 | — |
| Reactant | 1,4-Dimethyl L-aspartate | HCID 111207 | — |
| Reactant | 5-Benzyl-3,6-dioxo-2-piperazine acetic acid methyl ester | HCID 13883773 | — |
| Product | 3-Carboxymethyl-6-benzyl-2,5-diketopiperazine | HCID 119494 | — |
| Product | 5-Benzyl-3,6-dioxo-2-piperazine acetic acid methyl ester | HCID 13883773 | — |
Reaction Steps
The present inventors have further found that 5-benzyl-3,6-dioxo-2-piperazine acetic acid methyl ester is also obtained by condensating and cyclizing the N-carboxylic acid anhydride of L-phenylalanine and L-aspartic acid dimethyl ester in an organic solvent, and 5-benzyl-3,6-dioxo-2-piperazine acetic acid is obtained by hydrolyzing 5-benzyl-3,6-dioxo-2-piperazine acetic acid methyl ester with an alkali, if necessary.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04780561 |
| Source dataset | uspto-grants-1988_10 |
| ORD ID | ord-77b890b0dece4c55852b79365879fd66 |
| Source note | uspto-grants-1988_10 |