2-(Bromomethyl)pyridine hydrobromide → HCID 57330885, compound

HRID 868732Notes

Reaction equation

HRID 868732 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:8]2[NH:9][C:10](=[S:13])[NH:11][N:12]=2)[O:5][C:6]=1[CH3:7].Br.Br[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1>>[CH3:1][C:2]1[CH:3]=[C:4]([C:8]2[NH:12][N:11]=[C:10]([S:13][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)[N:9]=2)[O:5][C:6]=1[CH3:7]

Participants

3

Reactant 2

HCID 27347202-(Bromomethyl)pyridine hydrobromideHCID 178423532HCID 178423532, compound

Product 1

HCID 57330885HCID 57330885, compoundYield 27%

Procedure

Prepared in a similar manner to example 1 using 5-(4,5-dimethylfuran-2-yl)-2H-1,2,4-triazole-3(4H)-thione (example 5a) and 2-(bromomethyl)pyridine hydrobromide. Yield 27%. 1H NMR (500 MHz, dMSO): δ 1.98 (s, 3H), 2.28 (s, 3H), 4.37 (s, 2H), 6.76 (s, 1H), 7.3 (m,1H), 7.45 (d, 1H), 7.75 (t, 1H), 8.6 (s, 1H). MS(M+H, 287).

Sources & evidence

ORD record
ord-289c166267ed477d8e38c48281b43ffe
Source dataset
uspto-grants-2015_03
Patent number
US08968708B2

Reaction notes

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