2-(Bromomethyl)pyridine hydrobromide → HCID 57330885, compound

HRID 868733Notes

Reaction equation

HRID 868733 reaction equation
[O:1]1[C:5]2[CH:6]=CC=[CH:9][C:4]=2[CH:3]=[C:2]1[C:10]1[NH:11][C:12](=[S:15])[NH:13][N:14]=1.Br.Br[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=1>>[CH3:9][C:4]1[CH:3]=[C:2]([C:10]2[NH:14][N:13]=[C:12]([S:15][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=3)[N:11]=2)[O:1][C:5]=1[CH3:6]

Participants

3

Reactant 2

HCID 27347202-(Bromomethyl)pyridine hydrobromideHCID 178527911HCID 178527911, compound

Product 1

HCID 57330885HCID 57330885, compoundYield 59%

Procedure

Prepared in a similar manner to example 1 using 5-(benzofuran-2-yl)-2H-1,2,4-triazole-3(4H)-thione (example 6a) and 2-(bromomethyl)pyridine hydrobromide. Yield 59%. 1H NMR (500 MHz, CDCl3): δ 4.37 (s, 2H), 7.26-7.34 (m, 5H), 7.4-7.42 (d,1H), 7.55-7.57 (d, 1H), 7.65-7.67 (d, 1H), 7.75 (t, 1H), 8.62 (s, 1H). MS(M+H, 309).

Sources & evidence

ORD record
ord-c290744ad245432db13df4a3a2ad5758
Source dataset
uspto-grants-2015_03
Patent number
US08968708B2

Reaction notes

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