3-Tert-butyl-1,2-oxazol-5-amine → HCID 71295250, compound

Participants

Reaction Conditions

Reaction Steps

100 mg of 5-(2-fluoropyridin-4-yl)-2-(tetrahydropyran-4-yloxy)benzonitrile are suspended in 6 ml of dioxane in a 50 ml three-necked flask under N2, 52 mg of 3-tert-butylisoxazol-5-ylamine and 79 mg of KOtBu are added. The yellow solution is stirred at 80° C. for 2.5 h. For work-up, the reaction mixture is evaporated in a rotary evaporator, the residue is taken up in ethyl acetate and water and extracted. The collected organic phases are dried, filtered and evaporated. The crude product is purified by preparative HPLC, giving the desired product in 46% yield; HPLC-MS Rt. [min] 2.556; HPLC-MS [M+H] 419;

Provenance & Evidence