Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | HCID 60925752 | HCID 60925752 | — |
| Reactant | 5-(2-Chloro-4-pyrimidinyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]benzonitrile | HCID 86671009 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 71509280 | HCID 71509280 | 25.8% |
Reaction Steps
5-(2-Chloropyrimidin-4-yl)-2-(tetrahydropyran-4-yloxy)benzonitrile (200 mg) are dissolved in ethanol and dioxane in a 100 ml three-necked flask, and the 1-(3-methoxypropyl)-1H-pyrazol-4-ylamine (129 mg) prepared above and 0.8 ml of triethylamine are added. The yellow solution is stirred at 100° C. for two days. For work-up, the mixture is evaporated in a rotary evaporator and purified by chromatography, giving 71 mg of the desired product; HPLC-MS Rt. [min] 2.041; HPLC-MS [M+H] 435;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08969335B2 |
|---|
| Source dataset | uspto-grants-2015_03 |
|---|
| ORD ID | ord-cbe8ecb6dd4e42efa111250281941df3 |
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| Source note | uspto-grants-2015_03 |
|---|
