HCID 68008520, compound → HCID 71295071, compound

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Reaction Steps

With 5-(2-chloropyridin-4-yl)-2-(tetrahydropyran-4-yloxy)benzonitrile and the 5-(3,6-dihydro-2H-pyran-4-yl)pyridin-2-ylamine prepared, 5-{2-[5-(3,6-dihydro-2H-pyran-4-yl)pyridin-2-ylamino]pyridin-4-yl}-2-(tetrahydropyran-4-yloxy)benzonitrile is obtained in 23% yield under the Buchwald-Hartwig conditions indicated; HPLC-MS Rt. [min] 1.717; HPLC-MS [M+H] 455;

Provenance & Evidence