HCID 71295118, compound → HCID 71295253, compound

HRID 868823Notes

Reaction equation

HRID 868823 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[CH:13]=[CH:12][C:11]([B:14]3[O:18][C:17]([CH3:20])([CH3:19])[C:16]([CH3:22])([CH3:21])[O:15]3)=[CH:10][C:7]=2[C:8]#[N:9])[CH2:3][CH2:2]1.Br[C:24]1C=CC(OCC2CCC2)=C(C=1)C#N>>[CH:1]1([CH2:4][O:5][C:6]2[CH:13]=[CH:12][C:11]([B:14]3[O:18][C:17]([CH3:20])([CH3:19])[C:16]([CH3:21])([CH3:22])[O:15]3)=[CH:10][C:7]=2[C:8]#[N:9])[CH2:2][CH2:24][CH2:3]1

Participants

3

Reactant 2

HCID 71295118HCID 71295118, compoundHCID 71295160HCID 71295160, compound

Product 1

HCID 71295253HCID 71295253, compound

Procedure

The preparation succeeds in a similar manner as described above for 2-cyclopropylmethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile with 5-bromo-2-cyclobutylmethoxybenzonitrile (5.0 g, 0.018 mol), giving 3.5 g of the desired product as colourless oil;

Sources & evidence

ORD record
ord-63f6147f5f8b433dad6da180dedee20e
Source dataset
uspto-grants-2015_03
Patent number
US08969335B2

Reaction notes

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