HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 86729195, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl 4-((2-cyano-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)methyl)piperidine-1-carboxylate | HCID 86729196 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 86729195 | HCID 86729195 | — |
Reaction Steps
HCl in dioxane (50 ml) is added to a solution of tert-butyl 4-[2-cyano-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxymethyl]piperidine-1-carboxylate (6.0 g, 0.0135 mol) in 1,4-dioxane (50 ml), and the mixture is stirred at room temperature for 16 h. The mixture is evaporated in a rotary evaporator and employed in the next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969335B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-cdcdf2c040c641299e5b5348b8b03a78 |
| Source note | uspto-grants-2015_03 |