Acetic Acid → HCID 86729197, compound

Participants

Reaction Steps

Glacial acetic acid (2.1 g, 0.035 mol), triethylamine (3.5 g, 0.035 mol) and 1-propanephosphonic anhydride (60% w/w in ethyl acetate) (11 ml, 0.0174 mol) are added to a solution of 2-(piperidin-4-ylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile (4.0 g, 0.0116 mol) in dichloromethane (40 ml) at 0° C. under nitrogen. The reaction is stirred at room temperature for 15 h. The solution is evaporated and poured into water (200 ml). The mixture is extracted with dichloromethane (100 ml×2) and evaporated in a rotary evaporator. The crude product is purified by chromatography, giving 6.0 g of the desired product as colourless oil;

Provenance & Evidence