Cesium carbonate → HCID 71295167, compound

Participants

Reaction Conditions

Reaction Steps

Caesium carbonate (0.17 g, 0.54 mmol) and 2-bromoethyl methyl ether (0.045 g, 0.325 mmol) are added to a solution of the 2-cyclopropylmethoxy-5-[2-(1H-pyrazol-4-ylamino)pyridin-4-yl]benzonitrile prepared above (0.09 g, 0.27 mmol) in dry DMF (2 ml). The reaction mixture is warmed at 80° C. for 8 h. Ice is added, and the mixture is extracted with ethyl acetate (2×50 ml). The organic phase is washed with water (1×25 ml) and dried over sodium sulfate. The mixture is then evaporated in a rotary evaporator. The crude product is purified by chromatography, giving 5.8 mg of the desired product as brown solid;

Provenance & Evidence