Hydrochloric Acid → HCID 71295226, compound

Participants

Reaction Steps

HCl in dioxane (10 ml) are added to a solution of tert-butyl 4-{3-[4-(3-cyano-4-cyclopropylmethoxyphenyl)pyridin-2-ylamino]pyrazol-1-yl}piperidine-1-carboxylate (0.12 g, 0.23 mmol) in 1,4-dioxane (10 ml). The entire mixture is stirred at room temperature for 6 h. The reaction solution is evaporated in a rotary evaporator and rendered basic using 10% sodium bicarbonate solution (20 ml). The mixture is stirred for 10 min. The solid is filtered off, washed with diethyl ether (20 ml) and dried, giving 85.4 mg of the desired material as brown solid;

Provenance & Evidence