HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1,1-Trifluoro-2-iodoethane → 5-fluoro-3-iodo-1-(2,2,2-trifluoroethyl)-1H-indazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1,1-Trifluoro-2-iodoethane | HCID 67709 | — |
| Reactant | HCID 178505475 | HCID 178505475 | — |
| Product | 5-fluoro-3-iodo-1-(2,2,2-trifluoroethyl)-1H-indazole | HCID 86723142 | 46% |
Reaction Steps
The title compound was prepared in 46% yield from 5-fluoro-3-iodo-indazole and 1,1,1-trifluoro-2-iodoethane according to the general procedure for Preparation 10A. The minor isomer was not isolated or characterized. 1H NMR (400 MHz, CDCl3): δ 4.91-4.97 (2H, m), 7.17 (1H, dd, J=2.0, 8.0 Hz), 7.30 (1H, td, J=2.0, 8.4 Hz), 7.38 (1H, dd, J=3.6, 9.2 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969343B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-35de4aaa0df340adb0fd0d1b61db280d |
| Source note | uspto-grants-2015_03 |