1-Bromo-2-methylpropane → 5-fluoro-3-iodo-1-(2-methylpropyl)-1H-indazole

Participants

Role	Name	HCID	Charge
Reactant	1-Bromo-2-methylpropane	HCID 6555	—
Reactant	HCID 178505475	HCID 178505475	—
Product	5-fluoro-3-iodo-1-(2-methylpropyl)-1H-indazole	HCID 86723144	70%

Reaction Steps

The title compound was prepared in 70% yield from 5-fluoro-3-iodo-indazole and 1-bromo-2-methylpropane according to the general procedure for Preparation 10A. The minor isomer was not isolated or characterized. 1H NMR (400 MHz, CDCl3): δ 0.92 (6H, d, J=6.8 Hz), 2.30-2.37 (1H, m), 4.16 (2H, d, J=7.2 Hz), 7.11 (1H, dd, J=2.4, 8.8 Hz), 7.19 (1H, td, J=2.4, 8.8 Hz), 7.32 (1H, dd, J=4.0, 8.8 Hz).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08969343B2
Source dataset	uspto-grants-2015_03
ORD ID	ord-538e3a3b54d8401a8d5ff3c5a3b8c115
Source note	uspto-grants-2015_03