1-Bromopropane → HCID 86723148, compound

HRID 868858Notes

Reaction equation

HRID 868858 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[I:11].Br[CH2:13][CH2:14][CH3:15]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:13][CH2:14][CH3:15])[N:6]=[C:5]2[I:11]

Participants

3

Reactant 2

HCID 78401-BromopropaneHCID 178477912HCID 178477912, compound

Product 1

HCID 86723148HCID 86723148, compoundYield 75%

Procedure

The title compound was prepared in 75% yield from 5-chloro-3-iodo-indazole and 1-bromopropane according to the general procedure for Preparation 10A. The minor isomer was not isolated or characterized. 1H NMR (400 MHz, CDCl3): δ 0.92 (3H, t, J=7.6 Hz), 1.91-1.97 (2H, m), 4.33 (2H, t, J=7.2 Hz), 7.31 (1H, d, J=8.8 Hz), 7.37 (1H, dd, J=2.0, 8.8 Hz), 7.46 (1H, d, J=1.2 Hz).

Workup

  1. customThe minor isomer was not isolated

Sources & evidence

ORD record
ord-972c69ccf44b498989f3413e325daa40
Source dataset
uspto-grants-2015_03
Patent number
US08969343B2

Reaction notes

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