1-Bromopropane → HCID 86723151, compound

HRID 868861Notes

Reaction equation

HRID 868861 reaction equation
[I:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH3:11])[CH:9]=2)[NH:4][N:3]=1.Br[CH2:13][CH2:14][CH3:15]>>[I:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH3:11])[CH:9]=2)[N:4]([CH2:13][CH2:14][CH3:15])[N:3]=1

Participants

3

Reactant 2

HCID 78401-BromopropaneHCID 178423510HCID 178423510, compound

Product 1

HCID 86723151HCID 86723151, compoundYield 60%

Procedure

The title compound was prepared in 60% yield from 3-iodo-5-methyl-indazole and 1-bromopropane according to the general procedure for Preparation 10A. The minor isomer was not isolated or characterized. 1H NMR (400 MHz, CDCl3): δ 0.92 (3H, t, J=7.2 Hz), 1.90-1.96 (2H, m), 4.32 (2H, t, J=7.2 Hz), 7.22-7.28 (3H, m).

Workup

  1. customThe minor isomer was not isolated

Sources & evidence

ORD record
ord-0b77d0892ec94e0c987777d3e34b3ac2
Source dataset
uspto-grants-2015_03
Patent number
US08969343B2

Reaction notes

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