1-Bromopropane → HCID 86723156, compound

HRID 868867Notes

Reaction equation

HRID 868867 reaction equation
[I:1][C:2]1[C:10]2[C:5](=[C:6]([CH3:11])[CH:7]=[CH:8][CH:9]=2)[NH:4][N:3]=1.Br[CH2:13][CH2:14][CH3:15]>>[I:1][C:2]1[C:10]2[C:5](=[C:6]([CH3:11])[CH:7]=[CH:8][CH:9]=2)[N:4]([CH2:13][CH2:14][CH3:15])[N:3]=1

Participants

3

Reactant 2

HCID 78401-BromopropaneHCID 178423854HCID 178423854, compound

Product 1

HCID 86723156HCID 86723156, compoundYield 62%

Procedure

The title compound was prepared in 62% yield from 3-iodo-7-methyl-indazole and 1-bromopropane according to the general procedure for Preparation 4A. The minor isomer was not isolated or characterized. 1H NMR (400 MHz, CDCl3): δ 0.94 (3H, t, J=7.4 Hz), 1.84-1.90 (2H, m), 2.66 (3H, s), 4.50 (2H, t, J=7.4 Hz), 7.01 (1H, t, J=7.1 Hz), 7.11 (1H, d, J=6.9 Hz), 7.28 (1H, d, J=8.0 Hz). [M+H] calc'd for C11H13FN2, 301; found 301.

Workup

  1. customThe minor isomer was not isolated

Sources & evidence

ORD record
ord-9e1918feea994fd39014477b68a3d137
Source dataset
uspto-grants-2015_03
Patent number
US08969343B2

Reaction notes

Loading…