2-Butyn-1-ol, 4-chloro- → HCID 86723158, compound

HRID 868870Notes

Reaction equation

HRID 868870 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[I:11].[Cl:12][CH2:13][C:14]#[C:15][CH2:16]O>>[Cl:12][CH2:13][C:14]#[C:15][CH2:16][N:7]1[C:8]2[C:4](=[CH:3][C:2]([F:1])=[CH:10][CH:9]=2)[C:5]([I:11])=[N:6]1

Participants

3

Reactant 2

HCID 2027752-Butyn-1-ol, 4-chloro-HCID 178505475HCID 178505475, compound

Product 1

HCID 86723158HCID 86723158, compoundYield 58%

Procedure

The title compound was prepared from 5-fluoro-3-iodo-indazole and 4-chloro-2-butyn-1-ol in 58% yield according to the general procedure for Preparation 31A. The minor isomer was not isolated or characterized.

Workup

  1. customThe minor isomer was not isolated

Sources & evidence

ORD record
ord-17facee4b17548eeb6468edcc46e62dd
Source dataset
uspto-grants-2015_03
Patent number
US08969343B2

Reaction notes

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