反应详情

To (4-phenylthiazol-2-yl)methanol (900 mg, 4.7 mmol) in DCM (10 mL) was added MnO2 (4 g, 47 mmol), and the mixture was stirred at room temperature for 3 hours. The reaction mixture was then filtered, washed with water, extracted with EtOAc and dried over anhydrous sodium sulfate. The solution was concentrated under vacuum to give a crude product, which was purified by column chromatography to afford the title compound as a yellow solid (360 mg).

1. filtrationThe reaction mixture was then filtered
2. washwashed with water
3. extractionextracted with EtOAc
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationThe solution was concentrated under vacuum
6. customto give a crude product, which
7. customwas purified by column chromatography