2-Methylquinoxaline → HCID 70648559, compound

HRID 868937Notes

Reaction equation

HRID 868937 reaction equation
[CH3:1][C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[N:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[N:15]=[CH:14][C:13]=1[CH:22]=[O:23]>CC(O)=O>[N:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[N:15]=[CH:14][C:13]=1[CH:22]([OH:23])[CH2:1][C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

4

Reactant 2

HCID 236862-MethylquinoxalineHCID 594088Quinoxaline-2-carbaldehyde

Product 1

HCID 70648559HCID 70648559, compoundYield 26.3%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 2-methyl quinoxaline (0.11 g, 0.76 mmol) and quinoxaline-2-carbaldehyde (0.16 g, 0.63 mmol) in AcOH (2 mL) was stirred for 1 hour at 70° C. The reaction mixture was concentrated and purified with reverse phase column chromatography to afford 1,2-di(quinoxalin-2-yl)ethanol (0.05 g) as a yellow solid. MS (ESI) m/z 303.1 (M+H+).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. custompurified with reverse phase column chromatography

Sources & evidence

ORD record
ord-bbcaf82f8fd4458498cc3f04c22608da
Source dataset
uspto-grants-2015_03
Patent number
US08969349B2

Reaction notes

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