Sodium Hydroxide → HCID 70649663, compound

HRID 868986Notes

Reaction equation

HRID 868986 reaction equation
[CH3:1][C:2]1[N:7]2[N:8]=[C:9]([CH2:11][CH2:12][C:13]3[CH:22]=[CH:21][C:20]4[CH:19]=[CH:18][C:17]5[O:23][CH2:24][CH2:25][N:26](C(=O)C)[C:16]=5[C:15]=4[N:14]=3)[N:10]=[C:6]2[C:5]([CH3:30])=[N:4][CH:3]=1.[OH-].[Na+]>CO>[CH3:1][C:2]1[N:7]2[N:8]=[C:9]([CH2:11][CH2:12][C:13]3[CH:22]=[CH:21][C:20]4[CH:19]=[CH:18][C:17]5[O:23][CH2:24][CH2:25][NH:26][C:16]=5[C:15]=4[N:14]=3)[N:10]=[C:6]2[C:5]([CH3:30])=[N:4][CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86687899HCID 86687899, compound

Product 1

HCID 70649663HCID 70649663, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
100 °C

Procedure

To a solution of 1-(9-(2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)ethyl)-2,3-dihydro-[1,4]oxazino[2,3-h]quinolin-1-yl)ethanone (10 mg, 0.025 mmol) in methanol (1 mL) was added 2 M NaOH (0.05 mL, 0.1 mmol) at room temperature. After stirring the mixture at 100° C. for 12 h, the solvent was removed. The crude product was purified using reverse phase column chromatography (7 mg).

Workup

  1. customthe solvent was removed
  2. customThe crude product was purified

Sources & evidence

ORD record
ord-44fdb9f03e2042aab4efe6e7a0d1b877
Source dataset
uspto-grants-2015_03
Patent number
US08969349B2

Reaction notes

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