Methanol → HCID 70097650, compound

HRID 868992Notes

Reaction equation

HRID 868992 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][C:5]([C:9]([OH:11])=[O:10])=[N:6][C:7]=1[CH3:8].S(Cl)([Cl:14])=O.[CH3:16]O>>[ClH:14].[CH3:1][C:2]1[N:3]=[CH:4][C:5]([C:9]([O:11][CH3:16])=[O:10])=[N:6][C:7]=1[CH3:8]

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 111264565,6-dimethylpyrazine-2-carboxylic Acid

Product 1

HCID 70097650HCID 70097650, compound

Procedure

To a solution of 5,6-dimethylpyrazine-2-carboxylic acid (580 mg, 3.82 mmol) in methanol (20 mL) was added thionyl chloride (1.82 g, 15.3 mmol) slowly at 0° C. and the mixture was stirred for 2 h and then heated to reflux for 16 h. The reaction was then cooled to r.t. and concentrated to give the crude product as a yellow solid (700 mg). MS (ESI): m/z 167.1 [M+H]+.

Workup

  1. temperatureheated
  2. temperatureto reflux for 16 h
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-038382677d194227ac4d08b647f9c5e7
Source dataset
uspto-grants-2015_03
Patent number
US08969349B2

Reaction notes

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