Propionic acid, 3-iodo-, methyl ester → HCID 89601716, compound

Participants

Reaction Steps

The title compound was prepared in analogy to the procedure described for example 74 but using the compound prepared in example 88 and 2 equivalents of 3-iodo-propionic acid methyl ester (Scapens, D.; Adams, H.; Johnson, T. R.; Mann, B. E.; Sawle, P.; Aqil, R.; Perrior, T.; Motterlini, R. Dalton Transactions 2007, 43, 4962-4973). The reaction mixture was stirred for 2 h at rt. The crude material was purified by silica gel column chromatography (heptane/ethyl acetate, 1:0→7:3→2:3) followed by preparative HPLC (Column: XBridge, 30×100 mm. Flow: 30 mL/min. Gradient: 30% to 60% B in 15 min, 60% B for 5 min, 60% to 90% B in 5 min; A=0.1% TFA in water, B=0.1% TFA in acetonitrile). tR: 1.42 min (LC-MS 3); ESI-MS: 596.3 [M+H]+ (LC-MS 3).

Provenance & Evidence