Methyl iodide → HCID 89601551, compound

Participants

Reaction Steps

The title compound was prepared in analogy to the procedure described for example 74 but using the compound prepared in example 88, 3 equivalents of KHMDS and 2 equivalents of methyl iodide. The reaction mixture was stirred for 2 h at rt. The crude material was purified by silica gel column chromatography (hexane/EtOAc, 4:1) followed by preparative HPLC (Column: AG/PP/C-18-15/025. Flow: 20 mL/min. Gradient: 25% B; A=0.1% TFA in water, B=acetonitrile/MeOH, 1:1). tR: 6.92 min (HPLC 2); ESI-MS: 524.1 [M+H]+ (LC-MS 2).

Provenance & Evidence