HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 869075Generated: October 30, 2026
4-Methyloxybenzyl chloride → 5-Chloro-1-(4-methoxy-benzyl)-3-nitro-1H-pyridin-2-one
https://huagongshe.com/reaction/869075
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Methyloxybenzyl chloride | HCID 69993 | — |
| Reactant | HCID 178526657 | HCID 178526657 | — |
| Product | 5-Chloro-1-(4-methoxy-benzyl)-3-nitro-1H-pyridin-2-one | HCID 89601329 | — |
Reaction Steps
The title compound was prepared in analogy to the procedure described for example 1 but using 5-chloro-3-nitropyridin-2-ol and 4-methoxybenzyl chloride. The reaction was stirred for 1 h at 80° C. The residue was purified by silica gel column chromatography (CH2Cl2/EtOAc, 8:2). tR: 0.91 min (LC-MS 4); ESI-MS: 295.2 [M+H]+ (LC-MS 4); Rf=0.59 (hexane/EtOAc, 1:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08969341B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-527adba788d54f73a05c2cbec902b596 |
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| Source note | uspto-grants-2015_03 |
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