反应详情

The title compound was prepared in analogy to the procedure described in step 184.2 but using ethyl 4-((4-cyano-3-fluorophenyl)(hydroxy)methyl)-1-(2-(dimethylamino)-4-methoxypyrimidin-5-yl)-5-isopropyl-1H-pyrazole-3-carboxylate (intermediate 191.3) and 5-amino-3-chloro-1-(4-methoxy-benzyl)-1H-pyridin-2-one (product from step 155.4). After the extraction, the crude product was purified by chromatography (Silicagel, Hexane/EtOAc 50:50 to 20:80). Pure fractions were collected and evaporated to dryness to afford a brown solid.

1. extractionAfter the extraction
2. customthe crude product was purified by chromatography (Silicagel, Hexane/EtOAc 50:50 to 20:80)
3. customPure fractions were collected
4. customevaporated to dryness
5. customto afford a brown solid