Pyridine → Tert-butyl 2-[[acetyl-[4-(4-methoxyphenoxy)-2-pyrimidin-5-ylpyrimidin-5-yl]amino]methyl]pyrrolidine-1-carboxylate

HRID 86909Notes

Reaction equation

HRID 86909 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([CH2:13][NH:14][c:15]2[c:16]([O:27][c:28]3[cH:29][cH:30][c:31]([O:34][CH3:35])[cH:32][cH:33]3)[n:17][c:18](-[c:21]3[cH:22][n:23][cH:24][n:25][cH:26]3)[n:19][cH:20]2)[CH2:10][CH2:11][CH2:12]1.[CH3:36][C:37]([Cl:38])=[O:39].[Cl:46][CH2:47][Cl:48].[cH:40]1[cH:41][cH:42][n:43][cH:44][cH:45]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([CH2:13][N:14]([c:15]2[c:16]([O:27][c:28]3[cH:29][cH:30][c:31]([O:34][CH3:35])[cH:32][cH:33]3)[n:17][c:18](-[c:21]3[cH:22][n:23][cH:24][n:25][cH:26]3)[n:19][cH:20]2)[C:37]([CH3:36])=[O:39])[CH2:10][CH2:11][CH2:12]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 6367Acetyl chlorideHCID 178492507HCID 178492507, compound

Product 1

HCID 76714065Tert-butyl 2-[[acetyl-[4-(4-methoxyphenoxy)-2-pyrimidin-5-ylpyrimidin-5-yl]amino]methyl]pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-aa989194d75643d79ee0a2f343177fcc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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