HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Difluoropyridine → HCID 67452252, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Difluoropyridine | HCID 73934 | — |
| Reactant | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| Reactant | [1-(4-fluorophenyl)cyclobutyl]methanamine | HCID 24274221 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 67452252 | HCID 67452252 | 64% |
Reaction Steps
Following the same procedure as described for 2-(3-fluoropyridin-2-yl)acetonitrile (Example 18), 2,6-difluoropyridine (5.0 g, 43 mmol, 1.0 equiv), cyclobutylcarbonitrile (3.5 g, 43 mmol, 1.0 equiv) and NaHMDS (2.0 M in THF, 24 mL, 47 mmol, 1.1 equiv) in toluene (100 mL) gave the desired product (4.9 g, 64%) as a colorless oil following purification over silica gel using 25% EtOAc/hexanes as eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969346B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-f1e5187536184a02ba81b3b2425fa49c |
| Source note | uspto-grants-2015_03 |