Ammonia → HCID 68232027, compound

HRID 869203Notes

Reaction equation

HRID 869203 reaction equation
[C:1]([O:5][C:6]([N:8]([CH2:25][C:26]1([C:30]2[C:35]([F:36])=[CH:34][CH:33]=[CH:32][N:31]=2)[CH2:29][CH2:28][CH2:27]1)[C:9]1[N:14]=[N:13][C:12]([C:15]2[S:16][C:17]([C:20]([O:22]CC)=O)=[CH:18][N:19]=2)=[CH:11][CH:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH3:37]>CO>[C:20]([C:17]1[S:16][C:15]([C:12]2[N:13]=[N:14][C:9]([N:8]([CH2:25][C:26]3([C:30]4[C:35]([F:36])=[CH:34][CH:33]=[CH:32][N:31]=4)[CH2:27][CH2:28][CH2:29]3)[C:6](=[O:7])[O:5][C:1]([CH3:2])([CH3:4])[CH3:3])=[CH:10][CH:11]=2)=[N:19][CH:18]=1)(=[O:22])[NH2:37]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 67451804HCID 67451804, compound

Product 1

HCID 68232027HCID 68232027, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
120 °C

Procedure

To a solution of ethyl 2-(6-(tert-butoxycarbonyl((1-(3-fluoropyridin-2-yl)cyclobutyl)methyl)amino)pyridazin-3-yl)thiazole-5-carboxylate (162 mg, 0.32 mmol) in MeOH (8 mL) was purged with NH3 gas for 5 min. The reaction mixture was sealed and heated in a microwave reactor for 30 min at 120° C. The reaction mixture was concentrated and used in next step without purification, LRMS (M+H+) m/z 484.2.

Workup

  1. customThe reaction mixture was sealed
  2. concentrationThe reaction mixture was concentrated
  3. customused in next step without purification, LRMS (M+H+) m/z 484.2

Sources & evidence

ORD record
ord-3cf41ae49e8e4cfbabe795de72a08b1e
Source dataset
uspto-grants-2015_03
Patent number
US08969346B2

Reaction notes

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