HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 869207Generated: October 30, 2026
Potassium Carbonate → HCID 68231539, compound
https://huagongshe.com/reaction/869207
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Cyanothiophene-2-boronic acid | HCID 4198743 | — |
| Reactant | HCID 86686131 | HCID 86686131 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 68231539 | HCID 68231539 | 32% |
Reaction Steps
t-Butyl 6-chloropyridazin-3-yl((1-(3-fluoropyridin-2-yl)cyclobutyl)methyl)carbamate (900 mg, 2.29 mmol, 1 equiv), 5-cyanothiophen-2-ylboronic acid (390 mg, 2.52 mmol, 1.1 equiv), (dppf)PdCl2 (164 mg, 0.23 mmol, 0.1 equiv), nitrogen-sparged dioxane (6.0 mL) and aq. 2 N K2CO3 (2.3 mL) were combined and heated in a microwave reactor for 30 min at 140° C. The reaction mixture was filtered through a Celite plug and the filtrate was concentrated. The resulting residue was purified on silica gel using a mixture of ethyl acetate and hexanes to provide the title compound as a yellow oil (340 mg, 32%), LRMS (M+H+) m/z 466.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08969346B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-e5ffe06bd8ab4359aa40bdc2a1b07d9a |
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| Source note | uspto-grants-2015_03 |
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