1,4-Dioxane hydrochloride → HCID 66642763, compound

HRID 869227Notes

Reaction equation

HRID 869227 reaction equation
[CH:1]([C:4]1([OH:18])[CH2:9][CH2:8][CH:7]([NH:10]C(=O)OC(C)(C)C)[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[ClH:19].O1CCOCC1>O1CCOCC1>[ClH:19].[NH2:10][CH:7]1[CH2:8][CH2:9][C:4]([CH:1]([CH3:3])[CH3:2])([OH:18])[CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 68041886HCID 68041886, compound

Product 1

HCID 66642763HCID 66642763, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a mixture of tert-butyl (4-isopropyl-4-hydroxycyclohexyl)carbamate (Preparation Example 250) (0.392 g) and dioxane (3 mL), 26% hydrogen chloride-dioxane (2.0 mL) was added under ice cooling and stirred at room temperature for 18 hours. The precipitated solid was collected by filtration to give 4-amino-1-isopropylcyclohexanol hydrochloride (0.190 g) as a white solid.

Workup

  1. additionwas added under ice cooling
  2. filtrationThe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-a73a2330492b4b9b8572028e72970fe5
Source dataset
uspto-grants-2015_03
Patent number
US08969336B2

Reaction notes

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