1,4-Dioxane hydrochloride → HCID 66642763, compound

Participants

Reaction Steps

To a mixture of tert-butyl (4-isopropyl-4-hydroxycyclohexyl)carbamate (Preparation Example 252) (0.179 g) and dioxane (1.5 mL), 26% hydrogen chloride-dioxane (0.9 mL) was added under ice cooling and stirred at room temperature for 18 hours. The precipitated solid was collected by filtration to give 4-amino-1-isopropylcyclohexanol hydrochloride (0.086 g) as a white solid.

Provenance & Evidence