HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 869237Generated: October 29, 2026
Dimethylformamide → HCID 66642837, compound
https://huagongshe.com/reaction/869237
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | HCID 86662045 | HCID 86662045 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 66642837 | HCID 66642837 | 97.7% |
Reaction Steps
To a mixture of 4-chloro-2-(methylsulfanyl)-6-(quinolin-3-ylamino)pyrimidine-5-carboxamide (Preparation Example 344) (0.68 g) and sodium acetate (0.80 g), DMF (7 mL) was added and stirred at 100° C. for 6 hours. After the reaction liquid was returned to room temperature, water was added, and the resulting solid was collected by filtration to give 5-carbamoyl-2-(methylsulfanyl)-6-(quinolin-3-ylamino)pyrimidin-4-yl acetate (0.71 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08969336B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-d70306db52874d9783938242ed017b3b |
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| Source note | uspto-grants-2015_03 |
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