Boron tribromide → HCID 67419432, compound

Participants

Reaction Steps

To a solution of 625 mg (1.96 mmol) 2-[4-chloro-3-(trifluoromethyl)phenyl]-5-methoxy-3-methylpyrimidin-4(3H)-one in 25 ml CH2Cl2 was added 5.88 ml (5.88 mmol) of a 1 M solution of BBr3 in CH2Cl2. The reaction mixture was stirred for 1 h, then quenched with 25 ml MeOH, and concentrated in vacuo. Purification by HPLC gave 418 mg (70% yield) of 2-[4-chloro-3-(trifluoromethyl)phenyl]-5-hydroxy-3-methylpyrimidin-4(3H)-one. 1H NMR δ (ppm) (CDCl3): 7.86 (1H, d, J=1.95 Hz), 7.73 (1H, s), 7.67-7.61 (2H, m), 3.54 (3H, s). HRMS (ESI positive) calc (M+H)+=305.0299 found 305.0300.

Provenance & Evidence