Triethylamine → HCID 67284343, compound

Participants

Reaction Steps

To a solution of 3-(3-amino-phenyl)-2-(2-amino-pyrimidin-4-yl)-4-oxo-1,4,6,7-tetra-hydro-pyrrolo[3,2-c]pyridine-5-carboxylic acid tert-butyl ester (30 mg, 0.070 mmol) (prepared as described in Example 1) in dichloromethane (1 mL), 3-fluoro-benzene-sulfonyl chloride (0.010 mL, 0.077 mmol) and a drop of triethylamine were added. The mixture was stirred until disappearance of the starting material. The solvent was evaporated and the residued was suspended in diethylether and filtered to give 20 mg of 2-(2-amino-pyrimidin-4-yl)-3-[3-(3-fluoro-benzenesulfonylamino)-phenyl]-1-methyl-4-oxo-1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridine-5-carboxylic acid tert-butyl ester. (y: 50%)

Provenance & Evidence