HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 869337Generated: October 29, 2026
2,6-Dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine → 2-Chloro-9-(tetrahydropyran-2-yl)adenine
https://huagongshe.com/reaction/869337
Participants
| Role | Name | HCID | Charge |
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| Reactant | 2,6-Dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine | HCID 270265 | — |
| Reactant | Ammonia methanol | HCID 21705897 | — |
| Product | 2-Chloro-9-(tetrahydropyran-2-yl)adenine | HCID 12777819 | — |
Reaction Steps
2,6-dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine (55 g) was dissolved in 7N ammonia-methanol solution, and heated in a sealed flask at 100° C. for 6 hours. The reaction mixture was cooled to room temperature, followed by standing overnight and filtration to give the titled compound. Yield: 40 g (80%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08969362B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-f84e66f842744ad082d2c3099cc17412 |
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| Source note | uspto-grants-2015_03 |
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