HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Methyl [3-({[4-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)butyl][3-(2-oxopyrrolidin-1-yl)propyl]amino}methyl)phenyl]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(3-Aminopropyl)-2-pyrrolidinone | HCID 82111 | — |
| Reactant | (3-Bromomethyl-phenyl)-acetic acid methyl ester | HCID 10014651 | — |
| Reactant | 9-(4-Bromobutyl)-2-butoxy-8-methoxyadenine | HCID 23158511 | — |
| Product | Methyl [3-({[4-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)butyl][3-(2-oxopyrrolidin-1-yl)propyl]amino}methyl)phenyl]acetate | HCID 11706932 | — |
Reaction Steps
Using the compound obtained in Example 2-13 step (i) (400 mg), 1-(3-aminopropyl)pyrrolidin-2-on (1 ml), potassium carbonate (175 mg) and methyl [3-(bromomethyl)phenyl]acetate (175 mg), the same manner to Example 2-29 was conducted to give the titled compound as a white solid. Yield: 200 mg (48%); mp 115-116° C., MS APCI+ve 582 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969362B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-37f4c038df9f44d994210c6e2f6d5edd |
| Source note | uspto-grants-2015_03 |